MiR-155 contribute to airway inflammation in COPD by regulating autophagy via targeting TLR4/NF-ΚB

Targeting miR-155 to Treat Experimental Scleroderma

Scleroderma is a refractory autoimmune skin fibrotic disorder. Alterations of microRNAs in lesional skin could be a new approach to treating the disease. Here, we found that expression of miR-155 was up regulated in lesional skin tissue from patients with either systemic or localized scleroderma, and correlated with fibrosis area. Then we demonstrated the potential of miR-155 as a therapeutic t...

Mycobacterium tuberculosis-induced miR-155 subverts autophagy by targeting ATG3 in human dendritic cells

Autophagy is a primordial eukaryotic pathway, which provides the immune system with multiple mechanisms for the elimination of invading pathogens including Mycobacterium tuberculosis (Mtb). As a consequence, Mtb has evolved different strategies to hijack the autophagy process. Given the crucial role of human primary dendritic cells (DC) in host immunity control, we characterized Mtb-DC interpla...

Airway Inflammation in COPD*

Inflammation of the airways has been regarded as a cardinal pathophysiologic feature of asthma for some 20 years. This concept has been based on evidence from a variety of sources: the histologic changes in the airway wall, hyperresponsiveness of the asthmatic airways to a wide range of natural and pharmacologic agents, the presence of activated inflammatory and immune cells and their mediators...

Eosinophilic airway inflammation in COPD

Chronic obstructive pulmonary disease is a common condition and a major cause of mortality. COPD is characterized by irreversible airflow obstruction. The physiological abnormalities observed in COPD are due to a combination of emphysema and obliteration of the small airways in association with airway inflammation. The predominant cells involved in this inflammatory response are CD8+ lymphocyte...

Stem cell depletion by inflammation-associated miR-155